Complex human adenoid tissue-based ex vivo culture systems reveal anti-inflammatory drug effects on germinal center T and B cells
Identifieur interne : 000480 ( Main/Exploration ); précédent : 000479; suivant : 000481Complex human adenoid tissue-based ex vivo culture systems reveal anti-inflammatory drug effects on germinal center T and B cells
Auteurs : Angelika Schmidt [Allemagne] ; Johanna E. Huber [Allemagne] ; Özen Sercan Alp [Allemagne] ; Robert Gürkov [Allemagne] ; Christoph A. Reichel [Allemagne] ; Matthias Herrmann [Allemagne] ; Oliver T. Keppler [Allemagne] ; Thomas Leeuw [Allemagne] ; Dirk Baumjohann [Allemagne]Source :
- EBioMedicine [ 2352-3964 ] ; 2020.
Abstract
Human immunology research is often limited to peripheral blood. However, there are important differences between blood immune cells and their counterparts residing in secondary lymphoid organs, such as in the case of germinal center (GC) T follicular helper (Tfh) cells and GC B cells.
We developed a versatile
Phenotypic changes of certain
Our optimized methods, assays, and mechanistic findings can contribute to a better understanding of human GC responses. These insights may be relevant for improving autoimmune disease therapy and vaccination efficacy.
This work was supported by a project grant under the joint research cooperation agreement of LMU Munich, LMU University Hospital, and Sanofi-Aventis Deutschland GmbH, as well as by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Emmy Noether Programme BA 5132/1-1 and BA 5132/1-2 (252623821), SFB 1054 Project B12 (210592381), and SFB 914 Project B03 (165054336).
Url:
DOI: 10.1016/j.ebiom.2020.102684
PubMed: 32114393
PubMed Central: 7049648
Affiliations:
- Allemagne
- Bavière, District de Cologne, District de Haute-Bavière, Rhénanie-du-Nord-Westphalie
- Bonn, Munich
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Le document en format XML
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<author><name sortKey="Herrmann, Matthias" sort="Herrmann, Matthias" uniqKey="Herrmann M" first="Matthias" last="Herrmann">Matthias Herrmann</name>
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<author><name sortKey="Keppler, Oliver T" sort="Keppler, Oliver T" uniqKey="Keppler O" first="Oliver T." last="Keppler">Oliver T. Keppler</name>
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<author><name sortKey="Baumjohann, Dirk" sort="Baumjohann, Dirk" uniqKey="Baumjohann D" first="Dirk" last="Baumjohann">Dirk Baumjohann</name>
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<affiliation wicri:level="3"><nlm:aff id="aff0007">Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Human immunology research is often limited to peripheral blood. However, there are important differences between blood immune cells and their counterparts residing in secondary lymphoid organs, such as in the case of germinal center (GC) T follicular helper (Tfh) cells and GC B cells.</p>
</sec>
<sec><title>Methods</title>
<p>We developed a versatile <italic>ex vivo</italic>
lymphoid organ culture platform that is based on human pharyngeal tonsils (adenoids) and allows for drug testing. We systematically phenotyped Tfh and GC B cell subsets in explant- and suspension cultures using multicolor flow cytometry and cytokine multiplex analysis.</p>
</sec>
<sec><title>Findings</title>
<p>Phenotypic changes of certain <italic>ex vivo</italic>
cultured immune cell subsets could be modulated by cytokine addition. Furthermore, we optimized an activation-induced marker assay to evaluate the response to T cell stimulation. We provide proof-of-concept that Tfh and GC B cells could be modulated in these cultures by different anti-inflammatory drugs in unstimulated states and upon activation with vaccine-derived antigens. For example, GC B cells were lost upon CD40L blockade, and clinically approved JAK inhibitors impacted Tfh and GC B cells, including down-regulation of their key transcription factor BCL6. BCL6 regulation was affected by IL-6 signaling in T cells and IL-4 in B cells, respectively. Furthermore, we demonstrated that JAK signaling and TNF signaling contributed to the stimulation-induced activation of tonsil-derived T cells.</p>
</sec>
<sec><title>Interpretation</title>
<p>Our optimized methods, assays, and mechanistic findings can contribute to a better understanding of human GC responses. These insights may be relevant for improving autoimmune disease therapy and vaccination efficacy.</p>
</sec>
<sec><title>Funding</title>
<p>This work was supported by a project grant under the joint research cooperation agreement of LMU Munich, LMU University Hospital, and Sanofi-Aventis Deutschland GmbH, as well as by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Emmy Noether Programme BA 5132/1-1 and BA 5132/1-2 (252623821), SFB 1054 Project B12 (210592381), and SFB 914 Project B03 (165054336).</p>
</sec>
</div>
</front>
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</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bavière</li>
<li>District de Cologne</li>
<li>District de Haute-Bavière</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Bonn</li>
<li>Munich</li>
</settlement>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Schmidt, Angelika" sort="Schmidt, Angelika" uniqKey="Schmidt A" first="Angelika" last="Schmidt">Angelika Schmidt</name>
</noRegion>
<name sortKey="Baumjohann, Dirk" sort="Baumjohann, Dirk" uniqKey="Baumjohann D" first="Dirk" last="Baumjohann">Dirk Baumjohann</name>
<name sortKey="Baumjohann, Dirk" sort="Baumjohann, Dirk" uniqKey="Baumjohann D" first="Dirk" last="Baumjohann">Dirk Baumjohann</name>
<name sortKey="Gurkov, Robert" sort="Gurkov, Robert" uniqKey="Gurkov R" first="Robert" last="Gürkov">Robert Gürkov</name>
<name sortKey="Herrmann, Matthias" sort="Herrmann, Matthias" uniqKey="Herrmann M" first="Matthias" last="Herrmann">Matthias Herrmann</name>
<name sortKey="Huber, Johanna E" sort="Huber, Johanna E" uniqKey="Huber J" first="Johanna E." last="Huber">Johanna E. Huber</name>
<name sortKey="Keppler, Oliver T" sort="Keppler, Oliver T" uniqKey="Keppler O" first="Oliver T." last="Keppler">Oliver T. Keppler</name>
<name sortKey="Leeuw, Thomas" sort="Leeuw, Thomas" uniqKey="Leeuw T" first="Thomas" last="Leeuw">Thomas Leeuw</name>
<name sortKey="Reichel, Christoph A" sort="Reichel, Christoph A" uniqKey="Reichel C" first="Christoph A." last="Reichel">Christoph A. Reichel</name>
<name sortKey="Reichel, Christoph A" sort="Reichel, Christoph A" uniqKey="Reichel C" first="Christoph A." last="Reichel">Christoph A. Reichel</name>
<name sortKey="Sercan Alp, Ozen" sort="Sercan Alp, Ozen" uniqKey="Sercan Alp O" first="Özen" last="Sercan Alp">Özen Sercan Alp</name>
</country>
</tree>
</affiliations>
</record>
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